Neurowell Clinical Research
Now Enrolling: A Neurometabolic Approach to PTSD (HB-01)
We’re evaluating whether an investigational combination of two long-approved medications can help restore healthy brain energy signaling in PTSD. This IRB oversight study provides active medication — no placebo, clinical monitoring, and personalized dose optimization.
- IRB Oversight
- Active Medication – No Placebo
- Specialist Care Team
Why This Study
Targeting Brain Energy—Not Just Symptoms
Emerging research suggests PTSD involves disrupted astrocyte-neuron energy support and dysregulated cellular “energy switches.” HB-01 is designed to address these pathways by combining two established medicines to support energy production and coordination. Use in PTSD is investigational and is being evaluated in this trial.
- Energy support hypothesis:
improve mitochondrial output and fuel routing to key circuits.
- Network coordination hypothesis:
Normalize astrocyte signaling to reduce “energy crisis” states.
- Whole-person monitoring
Cognitive, functional, and safety assessments at each visit.
HOW IT WORKS
HB-01 (Two Components, Dual Target)
- Component A: PPAR-γ pathway support
A long-approved medication hypothesized to help shift astrocytes from “conserve” to “support” mode and bolster mitochondrial efficiency. Safety monitored throughout.
- Component B: Calcium signaling balance
A well-established medicine hypothesized to stabilize astrocyte activity and reduce inefficient over-excitation in stress networks.
- Rationale: Pairing production + distribution support may yield broader effects than either alone.
WHO MAY QUALIFY
Eligibility Snapshot
Likely Candidates
- Adults (18+) with diagnosed PTSD or trauma-related symptoms
- Persistent brain fog, mental fatigue, or emotional blunting
- Limited response to prior treatments
- Stable on current medication (4+ weeks)
- Willing to complete study visits and assessments
Key Exclusions
- Active substance use disorder
- Pregnant or planning pregnancy during the study
- Severe uncontrolled cardiovascular conditions
- Other criteria per screening by the study physician
Study Benefits
- Active treatment for all (no placebo) participants
- Medication and study visits provided at no cost
- Specialist oversight with regular safety monitoring
Advanced Assessments
- Metabolic and cognitive measures to track changes
- Personalized dose optimization
- Optional plain-friendly summaries for your records
Fast Next Step
A confidential phone screen determines fit and answers your questions.
How symptoms can arise
Metabolic Mismatch
Under stress, astrocytes may prioritize conservation over support, reducing efficient fuel delivery to circuits that govern cognition and emotion.
CELLULAR "SWITCHES"
Energy Sensing
AMPK/mTOR signaling helps cells balance survival vs. performance; dysregulation is an active research focus in stress-related disorders.
NETWORK EFFECTS
Calcium Coordination
Astrocyte calcium activity coordinates local networks; instability can impair synchrony and resilience under stress.
Participant Perspective
“It felt like someone turned the lights back on. I could think clearly and be present again.”
-Study participant, Week 8 (individual experience; results vary)
WHAT TO EXPECT
Three Simple Steps
- Screen: Confidential call to review history and eligibility
- Evaluate: Baseline visit, labs as indicated, and assessments
- Begin: Start HB-01 with regular check-ins and optimization
Contact
Take the First Step
Our research team will answer questions and discuss eligibility.
Frequently asked questions
Cost? There is no cost for study medication or study visits.
Placebo? This protocol uses active medication for all enrolled participants.
Voluntary? Participation is voluntary; you may withdraw at any time.
Important Information & Disclaimers
HB-01 combines two FDA-approved medications for other conditions. Its safety and efficacy for PTSD are investigational and are being evaluated in this IRB oversight clinical study. The information above is not medical advice. You will receive and should review the informed consent documents before deciding whether to participate.